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JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM
Nature Communications 2019
879 Purity (HPLC) >= 95% Solubility DMSO
Product Name Pomalidomide-5'-PEG2-OH Synonyms CAS Number 2357113-24-5 Related CAS Molecular Formula C17H19N3O6 Molecular Weight 361
Mal-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB-PNP best JTP-74057) is an orally activeSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating leaving group, enabling efficient and selective conjugation of the payload to the linker. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as
