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JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM
DBCO has been widely used in click chemistry and reacts with azide without copper catalyst
27 Purity (HPLC) >= 95% Solubility DMSO
Product Name DBCO-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C90H115FN10O25 Molecular Weight 1755
Azide-Propionyl-Val-Cit-PAB(m-PEG8) ca JTP-74057) is an orally activeSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine (PSAR), to enhance aqueous solubility. Solubility and physicochemical properties can be finely tuned through selection
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