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researchers fused Escherichia coli dihydrofolate reductase (eDHFR) to a chimeric antigen receptor (CAR) and demonstrated that this fusion does not disrupt cell signaling or the CAR’s cytotoxic function
Ready for conjugation to a target protein ligand to form PROTACs containing Lenalidomide as cereblon ligand
5-ROX alkyne is an excellent azide-reactive fluorescent reagent for labeling alkyne-containing biological molecules through click chemitry
S)-AHPC-CO-PEG3-propargyl Synonyms CAS Number 2374122-30-0 Related CAS Molecular Formula C32H44N4O7S Molecular Weight 628
Mal-Propionyl-PEG8-Gly-Gly-Phe-Gly-PAB(m-PEG4)-MMAE Size:1mg researchers fused Escherichia coli dihydrofolateSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a
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