CA-PhN3 deuterium-labeled-ketone Linker substitution influences succinimide ring

Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates

and more importantly

Datasheet         MSDS        COA

AggFluors are quenched and remain non-fluorescent

CA-PhN3 deuterium-labeled-ketone Linker substitution influences succinimide ringHaloTag is a self labeling protein tag engineered from the haloalkane dehalogenase DhaA, originally isolated from Rhodococcus rhodochrous. Its active site binds chloroalkane (CA)substrates, forming an irreversible covalent bond. This stable linkage between the HaloTag protein and its ligand enables rapid and efficient isolation and purification of tagged proteins. CA PhN3 is a HaloTag ligand containing an azide functional group, which readily reacts