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Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates
The conventional maleimidocaproyl (MC) unit is replaced by Mal-Propionyl-PEG4 moiety to enhance aqueous solubility
614 Purity (HPLC) >= 95% Physical Appearance White Solid Optical Properties n/a Solubility DMSO
Its fluorescence is relatively pH-insensitive
Propargy-Gly(m-PEG4)-Gly-Gly-Phe-Gly-PAB-PNP Size:25mg Linker substitution influences succinimide ringSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing
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