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Case of the Locked Hothouse If ever there was a card that looked like someone just straight up designed it for Cube, Case of the Locked Hothouse is it

If breaking card parity wide open isn't enough, you have Kefka, Ruler of Ruin lurking on the back, which is a completely different kind of threat that maintains the front half's absurd card generation

Rest in Peace, Containment Priest, Relic of Progenitus, Nihil Spellbomb, and their ilk will shut you down hard, so keeping at least 1 piece of spot removal for these on hand should be a priority

Looked at another way, Oracle could even be considered the most powerful artifact of all, for it has the power to change what other cards do any time it wants