In a Two-Headed Giant game, Cryptolith Fragments mana ability causes each player to lose 1 life, so each team loses 2 life
Heres the list so far: Major gains (30% or more): Minor gains (10-30%): Chalice of the Void, Noble Hierarch, Through the Breach, Doubling Season, Horizon Canopy, Engineered Explosives, Ancestral Vision, Mox Opal, Crucible of Worlds, Dark Confidant, Scapeshift, Brushland, Fulminator Mage, Ancient Stirrings, Lotus Bloom

Aang's Iceberg Aang, Swift Savior Aboleth Spawn Accelerated Evolution Activated Sleeper Adaptive Shimmerer Ademi of the Silkchutes Aether Meltdown Affa Guard Hound Agent Venom Airtight Alibi Akoum Alchemist's Refuge Alexi's Cloak Alms Collector Aluren Ambrosia Whiteheart Ambush Gigapede Ambush Paratrooper Ambush Viper Ambush Wolf Amphibian Downpour Anafenza, Unyielding Lineage Ancient Stone Idol Angel of Grace Angel of Salvation Angel of the Dire Hour Animate Spell (playtest) Annie Flash, the Veteran Appa, Steadfast Guardian Appendage Amalgam Aquitect's Defenses Archangel Avacyn Archivist of Oghma Arlinn, the Pack's Hope Armaggon, Future Shark Armor of Thorns Ashcoat Bear Ashiok's Erasure Ashiok's Forerunner Asinine Antics Aspect of Manticore Aven Interrupter Aven Mindcensor Aven Reedstalker Avengers Assemble
She even has a back-breaking ultimate that gives you control of every nonland permanent until the end of the turn